parp inhibitor

BCRF 2008 Symposium 15

BRCA genes /  lifestyle factors and PARP inhibitors
Response by:
Mary-Claire King, PhD (from the audience)
American Cancer Society Professor, Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA
Alan Ashworth, BSc, PhD, FRS (from the audience)
Professor, Molecular Biology and Director, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK

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PARP Inhibitor Shows Specificity for BRCA Tumors - MedPage Today  "This tumor-specific defect can be exploited by using PARP inhibitors to induce selective tumor cytotoxicity, sparing normal cells," the authors said. "PARP inhibition in these tumor cells with deficient homologous-recombination repair generates ...

PARP Inhibitor shows very encouraging results in metastatic breast ... - Gerson Lehrman Group  PARP inhibitors affect cancer cells by altering their ability to replicate DNA and grow. In theory and in animal models, they work syngergistically with more traditional chemotherapy agents, since PARP inhibition should make chemotherapy (or any drug ...

PARP inhibitors asctive in BRCA1/2, triple-negative breast cancers - HemOncToday  BSI-201 is a small molecular PARP inhibitor that enhances the effects of chemotherapy-induced DNA damage. According to O'Shaughnessy, the drug demonstrated no dose-limiting toxicities in phase-1/2b studies either alone or in combination with ...

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